Saturday, April 28, 2018

SXSW 2018 Day 4 Session 2: Everyday ways to fight opression


Manal Al-Sharif
Leyla Hussein, Dahlia Project
Maria Toorpakai Wazir, Maria Toorpakai Foundation
Thor Halvorssen, Human Rights Foundation

Manal Al-Sharif – arrested for driving a car in Saudi Arabia
Leyla Hussein – Fights against Female Genital Mutilation (FGM)
Maria – Played Squash in Afghanistan, promotes female participation in sport

Maria had always broken rules, and was never taught to fear.  Living in Afghanistan, she burned her dresses and cut her hair short when she was seven years old, and her family supported her.  Sports introduced her to the west.
Manal was able to use her abilities as a computer scientist to set up online meetings and to help be safe online and prevent prosecution.

Thor: Each of you are accidental activists, correct?
Leyla: My job stands in contradiction to my activism; as a psychotherapist, I need to mostly be listening.  As an activist, I need to mostly act.  But what I bring as a psychotherapist is the ability to not just say “this is wrong” but rather to give facts and let the other side make their own conclusion; to avoid the curtain of objections coming down.  FGM will end not by workshops against it but instead by teaching about the body.
Maria: We need to communicate across communities to get people closer, and sport is a good way to do that.
Manal: Very hopeful for woman’s rights in Saudi Arabia.  High levels of woman education, large youth population, young leadership.  The concept of female guardianship – woman must have male guardian to do anything – campaigning to change the consciousness in society and leadership.

Thor: What drives you?
Leyla: Main driver for me was the birth of my daughter.  I did not want what happened to me to happen to her.  Outrage drives me.
Maria: It’s just part of who I am.
Manal: We should not be labeling people as one way or another, that brings up wall.
Leyla: Best to stay away from politics.
Manal: The main issue for me is to change guardianship system, which to me is the root of all evil.  Things are beginning to change slowly.

Thor: Focus on a narrow issue; narrow issues allow a wide coalition; wide issues narrow the coalition.

SXSW 2018 Day 4 Session 1: Extreme Bionics: The Future of Human Ability


Hugh Herr, Center for extreme bionics/MIT media lab
Aimee Mullins, Amiee Mullins Studio
Hans Gregor Naeder, Ottobock

The artificial limbs should extend our body as naturally as the smartphone extends our hand.  Today’s work in the field is on controlling living muscle tissue in high fidelity.
Some of the advancements researched today:
  • Injecting a virus that is sensitive to light, and use light to control motion
  • Special amputations in such a way that natural neural commands have a feedback allowing natural control of artificial limbs.  In the past, amputations were not as precise.

In two decades we’ll be able to build artificial limbs that surpass human ones, and the Paralympics will set better records than Olympics on comparable events.

Can we link human nervous systems with mechanical limbs?  There are promising advances in this domain.  Prosthetics are in transition from mere tools to natural extensions of the body.  We will not just be replacing limbs, we will be enhancing them.  Our limitations are only what we can imagine.  For example, when thinking about an exoskeleton for a paraplegic, could we create it with more than four limbs?  Could we create it with wings?  Would our brains adapt?

Q: What about affordability?  Will there be a disparity between what rich people can have vs. what poor people can?

A: It is similar to all tech.  Initially, only the rich will be able to afford it, but over time it will become available to all.

Monday, April 16, 2018

SXSW 2018 Day 3 Session 4: Business on the blockchain



Amber Baldet, leader of J.P. Morgan’s Blockchain center of excellence
Brian Behlendorf, Exec. Dir., Hyperledger

What are blockchains?
  • Distributed ledger
  • Smart contract
  • Enables storing and computing data without need for a central hub or authority

They can:
  • Record transfer of ownership of digital assets
  • Prevent double spend of these assets
  • Automate and enforce processes between participants
  • Be configured as private or public
  • Be censorship resistant

Decentralization of blockchain allows resistance of tampering.
What is a distributed ledger?
  • It is append-only log of transactions, distributed among network participants
  • Everyone sees the same data in the same order, guaranteed
  • Might have a governing body controlling access
  • Might manage assets

Smart contracts – smart contracts allow adding rules around the transactions such as “if-then” or conditionals.

How will businesses use this?  Experimentations are moving from the distributed DB to the public blockchain



Public blockchain, from a development standpoint, is like the internet in the 80’s, in terms of maturity.
Blockchains become more secure the more people you add to them.

In the traditional financial world, the initial thinking around blockchain was that it was a threat, because of bitcoin.  But once the mechanism was better understood, the financial world realized blockchain could be used to improve transactions at a lower cost.  Some of the use cases include payments, wholesale banking, digitization of existing sovereign fiat cash and others.
If the technology existing 15 years earlier, and was used for keeping home records and mortgages, it would have helped mitigate the 2008 financial crisis, as it would have made it easier to understand the housing market, and would have made it harder to hide toxic assets.

Outside of finance, blockchain is applicable to any other industry that uses transactions and that needs to get agreement by multiple parties about the facts on the ground.  Any supply chain can benefit from blockchain, and indeed we’re beginning to see entry of blockchain based ledgers in product industries.  In fishing, there are strict quotas, so a ledger tracking which fish was taken where is important.  In diamonds it’s important to establish the origin of the diamonds – that they are not blood diamonds.  In the shoe industries companies want to trace back their products to factories that use approved work practices, and so on.

Healthcare is another domain that can be revolutionized by blockchain.  Accreditation is a good example: when a doctor moves in the US from one state to another it can take weeks to get clearance to work, as you have delays looking up credentials in a trusted way from a central repository.  A public blockchain of doctor credentials would reduce that to almost instantaneous.
In general a blockchain system can change healthcare from a hub-spoke network to a distributed ledger model.
Healthcare records – you could make them more portable, be more patient centric rather than doctor centric.  You would store permissions and the ID info in the ledger, not the actual health records, as blockchain is not a good general purpose database.

Self sovereign ID - instead of being defined in a database, you have data in your wallet.  As you go through life, you accumulate more data in your records, and other sites can be given permission to view that data.  ID is not one thing, but a collection of identification contexts. There’s not one ID that fits everything about you; need to be able to aggregate together types of identity.


What other opportunities are there for disruption?
At this point it’s hard to tell.  It’s a lot harder than it seems, figuring out who owns data, compliance, how you upgrade and so on.  Nevertheless, blockchain removes the uncertainty of trust from transactions, enabling and enforcing verification; as such, businesses built on being the gateway or the central authority will need to rebuild themselves in the age of blockchain.
What about the energy consumption of blockchain?
Blockchain is purposefully computationally intensive for proof of work, but for many other things you don’t need blockchain to be so energy intensive, so we may see a reduction in the amount of energy needed to run a blockchain.  For smaller, private chains there may be other ways to do consensus management that don’t require computationally intensive processes.

What is the future of blockchain security in the age of Quantum computing?  Since the essence of blockchain is the hashing mechanism that locks blocks, there might be an impact.  One assumes that while quantum computing may potentially make cracking encryption easier, they will also likely enable new forms of encryption, so just use those in the blockchain.  Certainly the data itself in the blockchain should not be kept encrypted – just a hash of the data.  Regardless, the problem of quantum computers breaking encryption is a general one, not a specific one to blockchain.

How do you correct a mistake written in the blockchain? Can you pull data back out of the blockchain?  Since the whole point of the blockchain is to make a permanent trusted ledger, changing data in it is a hard problem to solve.  There’s no real way to claw back information.
There are three basic ways to delete data from a blockchain:
  1. Unwind, remove and reply the transactions – can be very expensive
  2. New algorithms applied that will enable “whiting out” records without having to rewrite the chain
  3. Everyone agrees not to look at the mistaken record.

What are the current technical challenges facing blockchain?
  • Governance – how do you manage something which no one owns
  • Scaling
  • Privacy (in a public chain)


SXSW 2018 Day 3 Session 5: Hacking Life: the Sci and Sci-Fi of immortality

Session page (no audio): https://schedule.sxsw.com/2018/events/PP80525

Jamie Metzl, Atlantic Council

The biggest revolution of our century is not the tech revolution, it’s the biotech revolution, and specifically the genetics/genomics revolution, all the biological connected systems that are going to change in a fundamental way.  After 3.8 Billion years of Evolution by Darwinian principles of random mutation and natural selection, we are turning a corner in Evolution towards a future where we are directing our own evolutionary path.

With all the advances of mapping, sequencing and precision editing the genom, we are beginning to hack the building blocks of life.  The fundamental change of biogenetic evolution is that we will realize our own genetic code is just another form of information technology.
When we see science fiction, we see so many advances in technology, but the people look just like we do now; but biology will not be constant.  If we had a time machine, and went back 1000 years in the past, and brought a baby back, it would grow up to be a regular human.  But if we took a baby from 1000 years in the future, it would grow up as a super-human among us – live longer, healthier, have special capabilities and traits we don’t see anywhere else.  This will take time to reach, but our improvements and the trajectory of change is increasing in exponential speed.  Among many things, this will change how long we live and how well we live our lives.

The search for longevity has driven a lot of the stories, myths and religions.  Gilgamesh looks for immortality, Methuselah lives to 969 years old; the Chinese have myths of a mushroom that gives immortality, and many other cultures were preoccupied with long life and immortality.

At the time of the Roman empire, average lifespan was 25; in 1900, average lifespan in the US was only 47 – 20 years increase over the span of several millennia.  But starting in the 19th century, rate started to increase dramatically as a result of better sanitation, nutrition and improvements in medicine.  During the 20th century average American lifespan extended at the rate of about three months a year, leading to today’s average of just under 80.  In 100 years we experienced the same rate of increase in lifespan we previously experienced over 3000 years.

What is still possible going forward?  It will not be possible to extend our lives beyond that of the oldest recorded human by continuing the same methods we used previously (improved nutrition, reduction of disease, improved lifestyle, improve safety).  So what else can be done to extend lifespan?
To answer this we first need to understand better what aging is.  Is aging a unified process, or a collection of separate and independent aging processes?  Is aging a degradation of the body, or an increase of accumulated knowledge, or a reduction of stem cells?  There is a lot of debate in the scientific community around what aging really is.  Also, there’s chronological aging and biological aging – the two don’t correlate the same way in all people.

There’s a big movement now to find the biological markers of aging.  There’s a lot of progress in understanding the mechanisms of aging, but still no linking it to an overarching system of aging.
Another question is whether there’s an evolutionary imperative for us to die of old age?  It doesn’t look like it – evolutionary selection works on reaction to environment or capabilities; there doesn’t seem to be an evolutionary system for cutting life off arbitrarily after a certain amount of time.  This used to correlate because with age capabilities degraded, but if they don’t, there doesn’t seem to be an evolutionary imperative to die.

Another thing to consider is that we are all decedents of humans who are survivors of near mass-starvation events; in several times in history the human population was reduced to a few thousand people (as recent as 75000 years ago).  This means that our ancestors were those who survived through incredible hardship, and we are descendants of these super resilient people, and we carry that resilient DNA.  If we can activate that we could possibly tap into some of that resiliency.

Alternatively, we can look at the longest living human.  The most credible record of longest living human is a French woman who lived to the age of 122.  There are also groups of people living to over 100 years old, and when you examine them to see what they have in common, you see it’s genetics.  Generally people who live very long lives live well in their long lives.

Another area of study is comparative biology of related animals.  For example, a mouse can live up to about 3 years in captivity, while its relative the naked mole rat can live up to 31 years – without showing signs of aging.  They also do not get cancer.  Another species studied is clams – regular clams live to about 15 years, but the ocean quahog clam can live several hundred years, with the oldest measured at 507 years old (clams add a ring to their shell every year, like trees).  They can live this long because of a low metabolism and mechanism to prevent oxidation.  A third example is the jellyfish, who have a lifespan ranging from a few hours to several months (depending on the species).  However, there is one species of jellyfish who is effectively immortal, because it can transform from adult to a polyp, essentially reversing aging, over and over.

Experimentation has been held in roundworms that have been selectively bred to long life.  Genetic analysis of roundworms of a long line of extended life compared with genetic data of regular roundworms shows there are relatively small number of genetic differences between the two types that can cause double or quadruple life (and healthier lives).  So scientists are studying the tradeoffs of turning these genetic markers off or on.

Some strategies for increasing lifespan:
Short term strategies:
  • Things we already know: exercise; low calorie, mostly plant-based diets; strong social networks; having a sense of purpose.  Exercising 1.5 hours a week increases overall lifespan by 2.5 years over everyone else who doesn’t exercise.  2.5 hours a week, adds 3 years more; 1 hour a day gives 4 additional years.
  • Calorie restriction diets: eating less calories than is required (~1200 calories a day).  Research now shows you don’t need to constantly be on a calorie restricted diet permanently; 5 consecutive calorie restricted days, in two months of an entire year are enough to get the same effect.
  • Drugs that trigger the effect of calorie restricted diets (Metformin, Rapamycin)
  • Once identifying the genes that correlate with older life, you can replicate the enzimes these genes create in people who don’t have these genes, producing the same effects as if they had them
  • Drugs that increase the number of times cells can reproduce
  • Reverse aging process of cells (similarly to how the immortal Jellyfish work), but less drastically
  • Blood rejuvenation – Research shows Parabiosis (sowing together a young moue and an old one, such that they share a blood system), rejuvenates the old mouse (while aging the young one).  Similar rejuvenation happened simply by injecting human cord blood into an old mouse.

Medium term strategies:
  • Large scale embryo selection through personalized precision genome sequencing
  • Precision personal medicine
  • Medical nanobots

Longer term strategies:
  • Immortality.  Increase the three months extension of life a year (current rate) to one year a year (unlikely).
  • Downloadable brain that can be uploaded into a new body



We will need to redefine our definitions of humanity the more we merge with technology.